Complete the form below to access this guide to sequencing epigenetic modifications. Epigenetics is the study of chemical modifications that can alter phenotype without altering nucleotide sequence. The most well-characterized and widely studied epigenetic modification in mammalian genomes, and especially in humans, is 5-methylcytosine (5mC) DNA methylation – the addition of a methyl group to a cytosine nucleotide. Download this guide to learn how to sequence DNA methylation directly from human genomes – without the need for PCR or additional library preparation steps. [ui-toggle title= title=”Contents”] In this guide, you will: Find out how direct DNA Oxford Nanopore sequencing enhances the analysis of epigenetic modifications Discover the benefits of Oxford Nanopore sequencing Identify the appropriate Oxford Nanopore sequencing kit for your experiment Read real-world case studies of how researchers are utilizing Oxford Nanopore sequencing to understand aberrant methylation in gene promoters and its association with disease For any questions, see the FAQs for this technique. [/ui-toggle] If you are unable to view the form below, you can access it here. hbspt.forms.create({ portalId: “6893718”, formId: “167a487b-d13e-480c-85b8-4e96d21d1a19”, region: “na1” }); This post was supported by Oxford Nanopore Technologies. The post Investigating methylation in the human genome with Oxford Nanopore appeared first on BioTechniques.
