AMSBIO reports how researchers from the Karolinska Institutet (Stockholm, Sweden) are using their Adeno Associated Virus (AAV) products in a groundbreaking investigation into the causes of rheumatoid arthritis (RA) pain. RA pain is not explained well by inflammation alone. In a new peer-reviewed study, the Swedish researchers describe the multitude of approaches they used to uncover the neural basis and causes of the inflammatory pain. In part of the study, the researchers used AAV products by AMSBIO to conditionally knockout Ifnar1 in sensory neurons and pharmacologically inhibit a key signaling pathway (IFN1/MNK–eIF4E) in mouse models on RA, which lead to alleviation of joint pain and restoration of dexterity and paw function. This pioneering AAV approach let the researchers functionally interrogate the exact joint-innervating neurons, rather than inferring joint involvement from skin sensitivity or broad dorsal root ganglion manipulation. The authors of the paper conclude that joint pain in RA is caused by a defined cytokine and signaling pathway, holding promise for targeted therapies for pain relief in arthritis. AMSBIO offers a comprehensive range of ready-to-use AAV products for both in vitro and in vivo applications. Read the paper in full. [ui-toggle title=”Contact AMSBIO” load=”hide”] +31-72-8080244 +44-1235-828200 +1-617-945-5033 info@amsbio.com [/ui-toggle] [ui-toggle title=”About AMSBIO” load=”hide”] AMSBIO, part of the Europa Biosite group, is a leading life sciences company supporting drug discovery, translational research and cell and gene therapy across Europe, North America and wider international markets. With in-depth expertise in advanced cell culture, 3D cell models and cryopreservation, AMSBIO is well placed to help researchers progress from early discovery through to clinical and GMP-ready applications. The company’s portfolio of innovative…
